Selected lectures that examine the intersection between sexual health and cardiovascular health, with a focus on the pharmacologic therapy for erectile dysfunction (ED). Lectures from US experts on the newest data on safety and cardiac interactions with PDE5 inhibitors, the workup for ED and associated cardiac risk factors in 2023, the role of CT Calcium scoring, the psychologic impact of ED, potential cardioprotective effects of PDE5 inhibitors, mechanism of action of PDE5 inhibitors, non-PDE5 inhibitor therapy for ED including restorative therapies (stem cell, shock wave therapy, platelet rich plasma), alternative therapies, PDE5 inhibitors in women, status of diagnostic and treatments for female sexual dysfunction.